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Maria-Veronica Ciocanel – Faculty Interview Lecture

January 30, 2020 @ 4:00 pm - 5:00 pm

Title:Topological Data Analysis for Describing Ring Channel Dynamics

Abstract:Contractile rings are structures made of actin filaments that are important in development, wound healing, and cell division. In many model organisms, ring channels allow nutrient exchange to developing egg cells and are regulated by forces exerted by myosin motor proteins. I will present an agent-based modeling and data analysis framework for the interactions between filaments and motor proteins inside cells. This approach may provide key insights for the mechanistic differences between two motors that are believed to maintain the rings at a constant diameter. In particular, we develop methods leveraging topological data analysis techniques to investigate time-series data of filament interactions. Our proposed methods clearly reveal the impact of kinetic parameters on significant topological hole formation, thus giving insight into ring channel formation and maintenance. I will also briefly discuss recent work on using machine learning approaches for recovering interaction networks in coupled phase-oscillator models and preliminary work for a quantitative study of federal sentencing disparities.


January 30, 2020
4:00 pm - 5:00 pm
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Phillips 332