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Simone Rossi, UNC-Chapel Hill – Colloquium

February 7, 2020 @ 4:00 pm - 5:00 pm

Title: Mathematical and Computational Modeling of the Heart

Abstract: Cardiovascular diseases are a major health and economic concern both in the U.S. and worldwide. Although recent breakthroughs in medical treatments for heart disease have improved patient outcomes, a complete understanding of the heart physiology is still lacking.​ In fact, the complex interplay between many interconnected physical phenomena has been a major obstacle in understanding the nonlinear physiology of the cardiac muscle.​ The development of mathematical and computational models has been critical for the quantitative understanding of the structure and function of the heart.​ And thanks to the advancements in medical imaging and the increase of computational power, current mathematical models can be used to guide diagnosis and therapies.​ On the other hand, it is still challenging to create a model of the heart that captures the basic physiology of the heart.​ By overcoming these limitations we will be able to create models for personalized treatments.​​

In this talk, I will show how we can translate mathematical and computational models into patient care. Specifically, I will present an ongoing project that aims to characterize the risk of stroke in patients affected by atrial fibrillation.​ I will give an example of how some models struggle to capture the large systolic deformations of the left ventricle. I will show how linking the heart microstructure with the macroscopic organ function leads to a more accurate description of the ventricular contraction, overcoming one of the most crucial limitations of most models. Finally, I will show some new exciting areas of research that aim to understand the formation of congenital heart defects and the morphomechanics of cardiac development.


February 7, 2020
4:00 pm - 5:00 pm
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