Jae Ho Lee (UNC Chapel Hill), GMA & Visions Seminar

Title: Fluid-structure interaction (FSI) model of in vitro left ventricle model

Abstract: Cardiovascular diseases (CVD) such as stroke, heart failure, and sudden cardiac death are the leading cause of death in the U.S. In 2013, CVD accounted for more than 17.3 million deaths globally, and this number is expected to grow to over 23.6 million by 2030. Computational modeling and simulation became increasingly useful in medical device design and surgical planning. The ultimate goal is to develop experimentally validated IBAMR-based fluid-structure interaction (FSI) models for developing optimal design and regulation for cardiovascular devices and improvement ins surgical planning. However, Experimentally validated computational models of cardiac FSI are lacking, and before such models can be widely deployed, substantial experimental and clinical validation is required. As an initial step, we focus on experimental validation of computational models of left ventricle (LV) model whose experimental result for the intraventricular fluid dynamics is readily available to compare to. In this talk, we will look at experimental and computational approaches, modeling, and some benchmark problems that will help answer questions that arise from this project.